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An improved process for the preparation of pramipexole dihydrochloride monohydrate.
专利权人:
发明人:
PATIL PRAVIN,PANSARE PRAKASH,JAGTAP ASHUTOSH,KRISHNAMURTHY DHILEEPKUMAR
申请号:
IN1307/MUM/2014
公开号:
IN2014MU01307A
申请日:
2014.04.09
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
The present invention relates to an improved process for the preparation of the dihydrochloride monohydrate salt of (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole (the compound of formula I) comprising reacting the compound of formula II with n-propanal and sodium borohydride using a mixture of methanol and dichloromethane (DCM) as the solvent to obtain the compound of formula I followed by converting the compound of formula I into its mono hydrochloride salt purifying the monohydrochloride salt of the compound of formula I and finally converting the pure monohydrochloride salt of the compound of formula I into the dihydrochloride monohydrate salt.
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