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POLYMORPHIC FORMS OF SODIUM SALT 4-Tret-Butyl-N- [4-CHLOR-2- (1-OXY-PYRIDIN-4-CARBONIL) -Phenyl] -BENZENESULPHANAMIDE
专利权人:
Инк. (US);ХЕМОЦЕНТРИКС
发明人:
БИС Джоанна (US),ИГО Давид Х. (US)
申请号:
RU2014104994/04
公开号:
RU2014104994A
申请日:
2012.07.20
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The crystalline form of the sodium salt of 4-tert-butyl-N- [4-chloro-2- (1-hydroxy-pyridin-4-carbonyl) phenyl] benzene sulfonamide, in which the crystalline form is characterized by an X-ray powder diffraction structure containing diffraction angles when measured using Cu radiation at approximately 4.0, 8.1, 10.1, 14.2, 16.2, 18.6, 20.3, 24.7, 25.0 and 26.5 ° 2θ.2. The crystalline form of the sodium salt of 4-tert-butyl-N- [4-chloro-2- (1-hydroxy-pyridin-4-carbonyl) phenyl] benzene sulfonamide, in which the crystalline form is characterized by an X-ray powder diffraction structure essentially according to FIG. 1.3. The crystalline form of the sodium salt of 4-tert-butyl-N- [4-chloro-2- (1-hydroxy-pyridin-4-carbonyl) phenyl] benzene sulfonamide, in which the crystalline form provides a Raman spectrum containing peaks at about 668, 743, 804, 1125, 1154, 1162, 1286, 1544, 1587, 1597, 1611, 1657 and 1672 cm. 4. The crystalline form of the sodium salt of 4-tert-butyl-N- [4-chloro-2- (1-hydroxy-pyridin-4-carbonyl) phenyl] benzene sulfonamide, in which the crystalline form provides the Raman spectrum essentially in accordance with FIG. 6.5. A pharmaceutical composition comprising a crystalline form according to any one of claims. 1-4 and a pharmaceutically acceptable carrier. 6. A method for preparing a pharmaceutical composition comprising mixing the crystalline form according to any one of claims 1 to 4 and a pharmaceutically acceptable carrier. The crystalline form of the sodium salt of 4-tert-butyl-N- [4-chloro-2- (1-hydroxy-pyridin-4-carbonyl) phenyl] benzene sulfonamide, in which the crystalline form is characterized by an X-ray powder diffraction structure containing diffraction angles at measurement using CuK radiation in approx1. Кристаллическая форма натриевой соли 4-трет-бутил-N-[4-хлор-2-(1-окси-пиридин-4-карбонил)-фенил]-бензолсульфонамида, в которой кристаллическая форма характеризуется рентгеновской порошковой дифракционной структурой, содержащей дифракци
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