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СОЧЕТАННАЯ ТЕРАПИЯ АФУКОЗИЛИРОВАННЫМ АНТИТЕЛОМ К CD20 И ИНГИБИТОРОМ MDM2
专利权人:
РОШ ГЛИКАРТ АГ (CH)
发明人:
ЭЛЬДЕРИНГ Эрик (NL),ГЕРТИНГ Франк (DE),КЛЯЙН Кристиан (CH),ВАН ОЭРС Маринус Х.Ё. (NL)
申请号:
RU2013131444/15
公开号:
RU2013131444A
申请日:
2011.12.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Afukozilirovannoe antibody to CD20 with fucose content of 60% or less of the total amount associated with the Asn297 oligosaccharides (sugar) in the treatment of cancer, in combination with an inhibitor MDM2.2. The antibody of claim 1, characterized in that said cancer is a cancer characterized by expression of CD20.3. The antibody of claim 1, characterized in that said cancer is characterized by expression of CD20, is a lymphoma or lymphocytic leykoz.4. The antibody of claim 1, wherein said antibody against CD20 is a humanized antibody B-Ly1.5. The antibody of claim 1, characterized in that said inhibitor MDM2 represents a) 4- [4,5-bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5-dihydro- imidazole-1-carbonyl] -piperazin-2-one, b) (4S, 5R) -1 - [[4 - [[4,5-bis (4-chlorophenyl) -2- [4- (tert-butyl) -2-ethoxy-phenyl] -4,5-dimethyl-4 5-dihydro-1H-imidazol-1-yl]] - carbonyl] -4- [3- (methylsulfonyl) propyl] piperazine, c) 2- {4 - [(4S, 5R) -2- (6-tert butyl-4-ethoxy-pyridin-3-yl) -4,5-bis- (4-chloro-phenyl) -4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl] -piperazin-1 -yl} -N, N-bis- (2-methoxyethyl) acetamide or d) 2- {1 - [(4S, 5R) -2- (6-tert-butyl-4-ethoxy-pyridin-3-yl) -4,5-bis- (4-chloro-phenyl) -4, 5-dimethyl-4,5-dihydro-imidazole-1-carbonyl] -piperidin-4-yl} -atsetamid.6. An antibody according to any one of claims. 1 to 5, characterized in that the administration is carried out one or more additional other cytotoxic, chemotherapeutic or anticancer agents or compounds or ionizing radiation, the reinforcing action such agentov.7. A composition for treatment of cancer, comprising a humanized antibody B-Ly1,1. Афукозилированное антитело к CD20 с содержанием фукозы 60% или менее от общего количества связанных с Asn297 олигосахаридов (сахаров) для лечения рака, в сочетании с ингибитором MDM2.2. Антитело по п.1, отличающееся тем, что указанный рак представляет собой рак, характеризующийся экспрессией CD20.3. Антитело по п.1, отличающееся тем, что указан
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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