WANG, JIN JEAN,YAKATAN, GERALD J.,LIN, TING N.,GAO, JING H.
申请号：
CA3038153
公开号：
CA3038153A1
申请日:
2018.05.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H1-receptor agonist, a histamine H2 -receptor agonist, a histamine H3-receptor antagonist, or a ß2-adrenoreceptor agonist. Also provided herein is a method of treating, preventing, or ameliorating a cardiovascular disease in a subject, comprising administering to the subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H1- receptor agonist, a histamine H2-receptor agonist, a histamine H3-receptor antagonist, or a ß2-adrenoreceptor agonist.
