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CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
专利权人:
The Broad Institute Inc.
发明人:
Zhang, Feng,Zetsche, Bernd
申请号:
AU2014361834
公开号:
AU2014361834A1
申请日:
2014.12.12
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotie cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends the engineering of optimized modular CRISPR-Cas enzyme systems.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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