Bryan T. Oronsky,Jan Scicinski,Susan Knox,William Fitch,Frans A. Kuypers,Marcel Fens,Sandra Larkin,Pedro Cabrales,Chad Brouse
申请号：
US16284035
公开号：
US20200022952A1
申请日:
2019.02.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
