Di (hetero) arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions containing them

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专利权人:

サノフイ

发明人:

トーマス・ベーメ,ウーヴェ・ゲルラッハ,ディルク・グレツケ,ハインツ－ヴェルナー・クレーマン,シュテファーニア・プファイファー－マレク,ヘニング・フォレルト,ジャン－ミッシェル・アルトンバージェ,セルギオ・マラー,ハインツ-ヴェルナー・クレーマン,シュテファーニア・プファイファー-マレク,ジャン-ミッシェル・アルトンバージェ

申请号：

JP2010510664

公开号：

JP5384485B2

申请日:

2008.05.23

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

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