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siRNA, recombinant vector expressing this siRNA, NR4A2 gene expression inhibitor, IL-17 gene expression inhibitor, and CD4 positive T cell proliferation inhibitor
专利权人:
財団法人ヒューマンサイエンス振興財団
发明人:
大木 伸司,北條 浩彦,三宅 幸子,山村 隆
申请号:
JP2009501299
公开号:
JP5098033B2
申请日:
2008.02.28
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
Disclosed are: an oligonucleotide useful for the inhibition of the production of IL-17, the inhibition of the proliferation of a CD4-positive T cell, the amelioration of an inflammation induced by IL-17 or the like; and an NR4A2 gene expression inhibitor, an IL-17 gene expression inhibitor, a CD4-positive T cell proliferation inhibitor or a pharmaceutical composition comprising the oligonucleotide as an active ingredient. Specifically disclosed is siRNA which can inhibit the expression of NR4A2 gene, such as an oligonucleotide having a nucleotide sequence depicted in any one of SEQ ID NOs:1 to 3. The siRNA is useful for the inhibition of the expression of NR4A2 gene, the inhibition of the expression of IL-17 gene, the inhibition of the proliferation of a CD4-positive T cell, the amelioration of an inflammation induced by IL-17 or the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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