Problem to be solved: to provide an antibody that targets low density lipoprotein associated protein 6 (LRP6), and its composition and method of use.Solution: a divalent antibody containing two antigen binding sites, the first antigen binding site is coupled to the propeller domain 1 of LRP6, the second antigen binding site is coupled to the propeller domain 3 of LRP6, and the lp6 signal transduction through the propeller 1 and propeller 3 Divalent antibodies that inhibit both Wnt1 and Wnt3 signaling and inhibit both.No selection【課題】低密度リポタンパク質関連タンパク質６（ＬＲＰ６）を標的とする抗体、並びに、その組成物及び使用の方法の提供。【解決手段】２つの抗原結合部位を含む二価抗体であって、第１の抗原結合部位がＬＲＰ６のプロペラドメイン１に結合し、第２の抗原結合部位がＬＲＰ６のプロペラドメイン３に結合し、前記二価抗体がプロペラ１とプロペラ３を介するＬＲＰ６シグナル伝達の両方を阻害し、かつ、Ｗｎｔ１およびＷｎｔ３シグナリングを増強しない、二価抗体。【選択図】なし
