JAESCHKE, GEORG,LINDEMANN, LOTHAR,MARTIN, RAINER E,RICCI, ANTONIO,RUEHER, DANIEL,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PH12015502692
公开号：
PH12015502692A1
申请日:
2015.12.02
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein Y is N or CH； R1 is hydrogen, fluoro or chloro； and R2 is hydrogen or lower alkyl； or to a pharmaceutically acceptable acid addition salt thereof. It has now surprisingly been found that the compounds of general formula (I) are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
