An anti-tumor traditional Chinese medicine, a preparation method therefor, and uses thereof. This traditional Chinese medicine is prepared by leavening of Pleurotus sp. and dioscorea bulbifera, pangolin scales, rhubarb, oyster, stiff silkworm, kelp, selfheal, ligusticum wallichii, barbat skullcap, honeysuckle flower, oldenlandia diffusa, radix trichosanthis, rhizoma anemarrhenae scutellaria baicalensis, angelica sinensis psoralea corylifolia, lucid ganoderma, and coix seed.