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Thieno [2,3-d] pyridazine derivatives and therapeutic use thereof for protein kinase inhibition
专利权人:
Wu; Zhanggui
发明人:
Wu, Zhanggui
申请号:
ES14164666
公开号:
ES2587509T3
申请日:
2010.09.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula I: ** Formula ** in which Y>; = O or S, R1>; = selected from the following groups: ** Formula ** in which X>; = CH2, NH, S or O, R8 >; = -H, -NH2, -OH, -N (R4, R5), -C (R4, R5) 1-7NR6R7, -C (R4R5) 1-7OR6, or N (R4) NR5R6, where R4 , R5, R6, R7>; = H, C1-C6 alkyls, C3-C8 cycloalkyls, with or without nuclear heteroatoms, such as O, S, and N, aryls (substituted or unsubstituted aromatics), or heteroaromatic (substituted or heteroaromatic unsubstituted), R9, R10, R11, R12, and R13>; = H, C1-C6 alkyls, C3-C8 cycloalkyls with or without nuclear heteroatoms such as O, S or N, aryls (substituted or unsubstituted aromatics), or heteroaromatic (substituted or unsubstituted heteroaromatic), R2 is selected from a group consisting of H, OH, NH2, OR14, NR14R15, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, in which R14, R15>; = H, C1-C6 alkyls, C1-C8 cycloalkyls with or without het nuclear eroatoms such as O, S, N, aryls (substituted or unsubstituted aromatics), or heteroaromatic (substituted or unsubstituted heteroaromatic), and R3 is selected from a group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl , heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl.Un compuesto de fórmula I:**Fórmula** en la que Y >;= O o S, R1 >;= seleccionado de los siguientes grupos:**Fórmula** en el que X >;= CH2, NH, S u O, R8 >;= -H, -NH2, -OH, -N(R4, R5), -C(R4, R5)1-7NR6R7, -C(R4R5)1-7OR6, o N(R4)NR5R6, en el que R4, R5, R6, R7 >;= H, alquilos C1-C6, cicloalquilos C3-C8, con o sin heteroátomos nucleares, tales como O, S, y N, arilos (aromáticos sustituidos o bien insustituidos), o heteroaromáticos (heteroaromáticos sustituidos o bien insustituidos), R9, R10, R11, R12, y R13 >;= H, alquilos C1-C6, cicloalquilos C3-C8 con o sin heteroátomos nucleares tales como O, S o N, arilos (aromáticos sustituidos o bien insustituidos), o heteroaromáticos (heteroaromáticos sustituidos o bie
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