The present invention relates, in some embodiments thereof, to systems, devices, and methods allowing for an engagement of two or more pharmaceutical vessels or pharmaceutical administration devices in a decontaminated manner. In some embodiments of the invention, the systems, devices and methods of the invention include a housing comprising a first compartment connectable to a first vessel's port； and a second compartment connectable to a second vessel's port, wherein the first and second compartments are engageable with each or integrally connected to each other, and wherein the first vessel is moveable within the housing from a first position wherein the vessel is connected to the first compartment, to a second position wherein the vessel is connected to the second compartment, wherein a substantially sterile aperture of the first vessel and/or second vessel is covered by a displaceable plate, and wherein prior to or at about the time of connection of the first vessel in the second position, the displaceable plate displaces from the aperture, allowing an substantially decontaminated engagement and fluid passageway between the first and second vessels.
