NUGENT, HELEN, MARIE,EDELMAN, ELAZER,DALAL, ANUPAM,BOLLINGER, STEVE,EPPERLY, SCOTT
申请号：
SG2013075387
公开号：
SG195537A1
申请日:
2006.06.05
申请国别(地区):
SG
年份:
2013
代理人:
摘要：
METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESSAbstractDisclosed is an implantable material comprising a biocompatible matrix and cells5 which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote foimation of a functional arteriovenous graft suitable for dialysis as well as10 promote formation of a functional peripheral bypass graft. Implantable material canbe configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain15 embodiments of the flexible planar fon I define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.(No suitable figure)
