КШИРСАГАР Раджеш,КАДАМ Чхандрашекар,МХАСКЕ Аджай,МУДДА См
申请号：
RU2012113380
公开号：
RU2012113380A
申请日:
2010.09.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. Ophthalmic composition containinga) dorzolamideb) timololc) brimonidined) w droksietiltsellyulozuand one or more pharmaceutically acceptable excipients.2. The composition of claim 1, wherein dorzolamide is present in an amount of 2% w / w of the formulation.3. The composition of claim 1 where timolol is present in an amount of 0.5% w / w of the formulation.4. The composition of claim 1, wherein brimonidine is present in an amount of 0.2% w / w of the formulation.5. The composition of claim 1 wherein hydroxyethyl cellulose is used as the amplifier stability.6. The composition of claim 1 wherein hydroxyethyl cellulose is used as the solubility of the amplifier.7. The composition of claim 1 wherein the viscosity of the composition is from about 20 cps to about 120 cps.8. The composition of claim 1, wherein the composition has a pH of from about 5 to about 7.9. The composition of claim 1, wherein the composition is packaged in a container made of LDPE.10. The composition of claim 1, wherein the composition is stable for more than six months.11. The composition of claim 1 wherein the composition droplet size is from about 35 ul to about 45 ml.12. The composition of claim 11, wherein the droplet size of the composition is 40 microliters.13. The composition of claim 1 where hydroxyethylcellulose has a viscosity of about 40 cps to about 200 cps.14. The composition of claim 1 wherein hydroxyethyl cellulose is present in an amount from about 0.1% w / v to about 1% w / v of the formulation.15. The composition of claim 14, where the hydroxyethyl cellulose is present in an amount from about 0.2% w / v to about 0.8% w / w of the formulation.16. The composition of claim 14 wherein the hydroxyethylcellulose is present in an amount from about 0.3% w / v to about 0.6% w / w of the formulation.17. A method of treating ocular hypertension through the use of a composition according to claim 1.18. A process for preparing an ophthalmic composition comprisinga) dorzolamideb) timololc) b
