Methods for treating or reducing the likelihood of acquiring estrogen related (e.g. estrogen exacerbated) diseases including endometriosis include administering to a patient a selective estrogen receptor modulator (SERM) in combination with inhibiting ovarian secretions e.g. by administering an LHRH agonist or antagonist. In some embodiments a precursor of sex steroids said precursor being selected from the group consisting of dehydroepiandrosterone (DHEA) dehydroepiandrosterone sulfate (DHEA S) androst 5 ene 3ß 17ß diol (5 diol) and androstenedione or a compound transformed into one of these is also administered
