Amanda Barbara MacKenzie;Andrew Graham Watts;Terrence Kantner
发明人:
Andrew Graham Watts,Amanda Barbara MacKenzie,Terrence Kantner
申请号：
US13378192
公开号：
US09452223B2
申请日:
2010.06.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Techniques to glycosylation are described, and more particularly to the production of glycosylation structures that are resistant to enzymatic degradation, thereby modulating one or more of their biological properties or those of therapeutic moieties incorporating them, and in particular to reacting activated carbohydrate substrates containing fluorine, such as 3-fluoro sialic acid compounds, with sugar acceptors to produce covalent conjugates of the sugar acceptor and one or more of the sialic acid compounds.
