The present invention provides quinazoline compounds. In particular, the invention provides certain quinazoline compounds which can inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR). The invention also provides the pharmaceutical compositions containing these quinazoline compounds and use of these compounds in the treatment of cancer.本發明提供了一類喹唑啉化合物。具體地,本發明提供了一類具有抑制表皮生長因子受體(Epidermal Growth Factor Receptor,EGFR)過度表達和/或活性過高的喹唑啉化合物。本發明還提供了含有該喹唑啉化合物的藥物組合物及其在治療癌症方面的應用。