Jeffrey R. Morgan,Toni-Marie Achilli,Anubhav Tripathi,Stephanie McCalla
申请号：
US13623599
公开号：
US09468680B2
申请日:
2012.09.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the spheroids. Uptake of a substrate of the efflux pump and distribution of a substrate for the efflux pump within the spheroids is imaged to thereby select drugs that inhibit the efflux pump or do not block gap junction communication. Selected drugs can then be employed to treat a tumor.
