A method of stabilizing a sensor in physiological parameter sensing applications during initialization of the sensor, comprises (a) applying a first voltage to an electrode in a sensor for a first timeframe； (b) applying a second voltage to an electrode in a sensor for a second timeframe； (c) making a measurement of an electrical characteristic of the sensor； and (d) based on the measurement, determining whether the sensor is stabilized. A corresponding blood glucose sensing system, comprises a sensor, the sensor including a plurality of electrodes； and a sensor electronics device, the sensor electronics device including circuitry configured (a) to provide a first voltage to one of the plurality of electrodes for a first timeframe, (b) to provide a second voltage to the one of the plurality of electrodes for a second timeframe, (c) to make a measurement of an electrical characteristic of the sensor and, (d) based on the measurement, to determine whether the sensor is stabilized. Also described is a program code storage device, comprising: computer-readable storage medium； and computer-readable program code, the computer-readable program code being stored on the computer-readable storage medium and having instructions, which when executed cause the glucose sensing system to (a) transmit a first signal to a digital-to-analogue converter (DAC), the DAC being coupled to an electrode of a sensor in physiological parameter sensing applications, the first signal representative of a first voltage that the DAC is to apply to the electrode for a first predetermined time； (b) transmit a second signal instructing the DAC to apply a second voltage to the electrode for a second predetermined time； (c) transmit a measurement signal to an analyzation module to cause the analyzation module to measure an electrical characteristic of the sensor； and (d) receive a third signal from the analyzation module indicating whether the sensor is stabilized based on the measurement.
