Combination therapies using late sodium ion channel blockers and potassium ion channel blockers

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专利权人:

GILEAD SCIENCES INC.

发明人:

BELARDINELLI LUIZ,RAJAMANI SRIDHARAN

申请号：

NZ62794213

公开号：

NZ627942A

申请日:

2013.01.25

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed herein is the use of a potassium channel blocker selected from the group consisting of bretylium, sotalol, ibutilide, dofetilide, azimilide, bretylium clofilium, E-4031, nifekalant, tedisamil, sematilide, fampridine and tertiapin, and one or more late sodium channel blockers of Formula I in the manufacture of a medicament for treating or preventing atrial fibrillation and/or atrial flutter or for prolonging atrial effective refractory period (ERP). Also disclosed are pharmaceutical compositions comprising the combinations.

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