YEGNASUBRAMANIAN, SRINIVASAN,NELSON, WILLIAM G.,VAGHASIA, AJAY,NUHN, PHILIPP
申请号：
CA3066350
公开号：
CA3066350A1
申请日:
2018.06.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
