<;P>;PROBLEM TO BE SOLVED: To provide a macrophage migration inhibition factor (MIF) secretion inhibitor. <;P>;SOLUTION: There are provided: the macrophage migration inhibition factor secretion inhibitor containing the extract of seeds of Benincasa cerifera Savi; an external preparation for skins, containing the macrophage migration inhibition factor secretion inhibitor; and an inflammatory disease-improving agent containing the macrophage migration inhibition factor secretion inhibitor. <;P>;COPYRIGHT: (C)2010,JPO&INPIT