ZHANG, XIAOKUI,YE, QIAN,LI, TIANJIAN,WANG, CHUAN,BHARATHAN, MINI,HERZBERG, URI,HARIRI, ROBERT J.
申请号：
CA3048979
公开号：
CA3048979A1
申请日:
2017.12.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD 16.
