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FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
专利权人:
DSM IP Assets B.V.
发明人:
Mirian Hendrika Jacoba GILLISSEN-VAN DER VIGHT,Jens Christoph THIES,Gueorgui MIHOV
申请号:
US16689569
公开号:
US20200087819A1
申请日:
2019.11.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (iv), wherein −;m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, −;m+p+q=1 whereby m or p could be 0, −;n is about 5 to about 300; (pref. 50-200), -Ri in independently selected from the group consisting of (C2-C20) alkykene or (C2-C20) alkenylene and combinations thereof; —;R and R in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, ()alkyl, ()alkenyl, (C-C)alkynyl, (C-Cio)aryl, —;(CH2)SH, —;(CH2)2S(CH), —;CH2OH, —;CH(OH)CH, —;(CH2)NH3, —;(CH2)NHC(—;NH2—;)NH2, —;CH2COOH, —;(CH2)COOH, —;CH2—;CO—;NH2, —;CH2CH2—;CO—;NH2, —;CH2CH2COOH, CH—;CH2—;CH(CH), (CH)2—;CH—;CH2—;, H2N—;(CH2), Ph-CH2—;, CH—;C—;CH2—;, HO-p-Ph-CH2—;, (CH)2—;CH—;, Ph-NH—;, NH—;(CH2)3—;C—;, NH—;CH═;N—;CH═;C—;CH2—;; —;R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, —;R is selected from bicyclic-fragments of 1,4,3,6-dianhydrohexitols of structural formula (III); —;R is selected from the group consisting of (C6-Cio)aryl, (GCeJalkyl, —;R is —;(CH2)4—;; whereby a is at least 0.05 and b is at least 0.05 and a+b−;.
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