THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
KLINMAN, DENNIS M.,GURSEL, MAYDA,GURSEL, IHSAN
申请号：
CA2620582
公开号：
CA2620582C
申请日:
2006.08.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
It is disclosed herein that agents that affect the activity and/or expressionof CXCLl6 can be used to alter the uptake of D-type CpG oligodeoxynucleo tides(D ODNs). Methods of inducing an immune response are disclosed that includeadministering agents that increase the activity and/or expression of CXCLl6and a D ODN. Methods of decreasing an immune response to a CpG ODN are alsodisclosed. These methods include administering an agent that decreases theactivity and/or expression of CXCLl6. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression ofCXCLl6 are provided.
