HÖGENAUER, Klemens;FERNANDES GOMES DOS SANTOS, Paulo Antonio;ZECRI, Frédéric;SOLDERMANN, Nicolas;STOWASSER, Frank;TUFILLI, Nicola;NOVARTIS AG;HOLLINGWORTH, Gregory
发明人:
FERNANDES GOMES DOS SANTOS, Paulo Antonio,HÖGENAUER, Klemens,HOLLINGWORTH, Gregory,SOLDERMANN, Nicolas,STOWASSER, Frank,TUFILLI, Nicola,ZECRI, Frédéric
申请号：
IBIB2012/053209
公开号：
WO2013/001445A1
申请日:
2012.06.25
申请国别(地区):
IB
年份:
2013
代理人:
摘要：
The invention relates to crystalline anhydrous forms, crystalline solvate forms and/or salt forms including crystalline salt forms of {(S)-3-[6-(6-methoxy-5-methyl-pyridin-3-yl)-5,6,7,8- tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy]-pyrrolidin-1-yl}-(tetrahydro-pyran-4-yl)-methanone or salt forms including crystalline salt forms of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl- pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-on； pharmaceutical compositions and combinations including these forms as well as to methods of using these forms, including their pharmaceutical compositions and combinations for the treatment of diseases.Cette invention concerne des formes anhydres cristallines, des formes solvates cristallines et/ou des formes sels comprenant les formes sels cristallines de la {(S)-3-[6-(6-méthoxy-5-méthyl-pyridin-3-yl)-5,6,7,8- tétrahydro-pyrido[4,3-d]pyrimidin-4-yloxy]-pyrrolidin-1-yl}-(tétrahydro-pyran-4-yl)-méthanone ou les formes sels comprenant les formes sels cristallines de la 1-{(S)-3-[6-(6-méthoxy-5-trifluorométhyl- pyridin-3-yl)-5,6,7,8-tétrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one ； des compositions pharmaceutiques et des combinaisons contenant ces formes ainsi que des procédés d'utilisation desdites formes, y compris leurs compositions pharmaceutiques et combinaisons pour le traitement des maladies.
