PROBLEM TO BE SOLVED: To obtain an intracellular substance transduction vector, having excellent stability and safety, capable of efficiently transferring as medicine, a gene or the like into a cell, useful for a drug delivery system or the like, by including a specific liposome. SOLUTION: This intracellular substance transduction vector for comprises a membrane fusion liposome obtained by fusing a virus having membrane fusion ability such as a vesicular stomatitis virus or its part with a liposome in which a substance such as a medicine, a gene or the like is enclosed, showing no hemolytic action or agglutination under physiological conditions.