An ultrasonic surgical device comprises a detachable transducer module, a handle, and a shaft assembly. The shaft assembly includes an end effector having a harmonic blade. The transducer module is removably coupled with the shaft assembly to form an active assembly. The active assembly is removably coupled with the handle. The handle may include a resilient wall structure that deflects outwardly to receive the active assembly in a snap fit. The handle may include a pivoting latch feature to selectively retain the active assembly relative to the handle.