The present disclosure provides methods for identifying fragments of a polypeptide that are immunogenic to a particular human subject, methods of preparing an individualized pharmaceutical composition comprising such a polypeptide fragment, human subjects comprising such a polypeptide fragment. To specific pharmaceutical compositions and methods of treatment using such compositions. The method involves the identification of fragments of the polypeptide that bind to multiple HLAs in the subject. [Selection diagram] None本開示は、特定のヒト被験者に対して免疫原性であるポリペプチドの断片を同定する方法、かかるポリペプチド断片を含む個別化された医薬組成物の調製方法、かかるポリペプチド断片を含むヒト被験者に特異的な医薬組成物、及びかかる組成物を使用した治療方法に関する。本方法は被験者の複数のＨＬＡに結合するポリペプチドの断片の同定を含む。【選択図】なし
