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Insulator to improve gene transfer vectors
专利权人:
FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD;INSTITUTO DE SALUD CARLOS III
发明人:
Francisco Martín Molina,Karim Benabdellah,Pilar Muñoz Fernández,Marién Cobo Pulido,Alejandra Gutierrez Guerrero
申请号:
US14776008
公开号:
US10053709B2
申请日:
2014.03.13
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention solves the problem of providing more efficient barrier insulators to avoid vector silencing and to increase expression in the setting of gene transfer vectors, more particularly in the setting of gene transfer retroviral vectors. In this sense, the authors of the present invention have developed an improved insulator element, namely element IS2, which comprises the following combination of nucleic acid molecules, namely nucleic acid molecule HS4-650 bp as shown in SEQ ID No 2 and a synthetic S/MAR nucleic acid molecule containing 5 M/SARs recognition signatures (MRS) as shown in SEQ ID no 1.
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