Rosa Maria Alvarez Escobar;Carmen Varela Busto;Joaquin Pastor Fernández;Ana Isabel Hernandez Higueras;Sonia Martinez Gonzalez;Sonsoles Rodriguez Aristegui;Esther Gonzales Cantalapiedra
发明人:
Joaquin Pastor Fernández,Sonia Martinez Gonzalez,Rosa Maria Alvarez Escobar,Sonsoles Rodriguez Aristegui,Esther Gonzales Cantalapiedra,Ana Isabel Hernandez Higueras,Carmen Varela Busto
申请号：
US13498059
公开号：
US20130029967A1
申请日:
2010.09.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
