HUMANIZED ANTIBODY FOR TREATING OR PREVENTING DEMENTIA AND PRODUCTION METHOD THEREFOR AND THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMENTIA USING SAME
PROBLEM TO BE SOLVED: To provide a humanized anti-phosphorylated tau antibody applicable as a therapeutic or prophylactic agent for dementia such as tauopathy in humans with reduced antigenicity to humans without substantially impairing the binding properties of mouse monoclonal anti-phosphorylated tau antibody to phosphorylated tau.SOLUTION: A humanized antibody or a fragment thereof that undergoes an antigen-antibody reaction with tau protein or tau peptide phosphorylated at least by an amino acid residue corresponding to Ser 413 among specific amino acid sequences, or a derivative thereof.SELECTED DRAWING: Figure 3【課題】マウスモノクローナル抗リン酸化タウ抗体のリン酸化タウに対する結合性を実質的に損なうことなく、ヒトに対する抗原性がより低減された、ヒトにおけるタウオパチー等の認知症の治療剤又は予防剤として適用可能なヒト化抗リン酸化タウ抗体の提供。【解決手段】特定のアミノ酸配列のうち、少なくともＳｅｒ４１３に相当するアミノ酸残基がリン酸化されたタウタンパク質又はタウペプチドに抗原抗体反応するヒト化抗体もしくはその断片、又はそれらの誘導体。【選択図】図３
