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Compound of spiro rings containing nitrogen and medicinal use thereof
专利权人:
Japan Tobacco; Inc.
发明人:
NOJI, Satoru,SHIOZAKI, Makoto,MIURA, Tomoya,HARA, Yoshinori,YAMANAKA, Hiroshi,MAEDA, Katsuya,HORI, Akimi,INOUE, Masafumi,HASE, Yasunori
申请号:
ES10804531
公开号:
ES2616705T3
申请日:
2010.07.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the following general formula [I]: ** Formula ** in which Ra is the same or different and each is: (1) C1-6 alkyl or (2) a halogen atom, n1 is an integer selected from 0 to 4, Rb is the same or different and each is: (1) C1-6 alkyl or (2) a halogen atom, n2 is an integer selected from 0 to 4, m1 is an integer selected from 0 to 3, m2 is an integer selected from 1 to 4, Xa>; = Xb is: (1) CH>; = CH, (2) N>; = CH or (3) CH>; = N, X is: (1 ) a nitrogen atom or (2) C-Rd in which Rd is a hydrogen atom or a halogen atom, Rc is a group selected from the following (1) to (6): (1) a hydrogen atom , (2) C1-6 alkyl optionally substituted with 1 to 5 identical or different substituents selected from the following Group A, (3) -C (>; = O) -Rc1, (4) -C (>; = O) - O-Rc2, (5) -C (>; = O) -NRc3Rc4 in which Rc1, Rc2, Rc3 and Rc4 are the same or different and each is: (i) a hydrogen atom or (ii) C1-6 alkyl optionally substituted with 1 to 5 identical or different substituents selected from the following Group A or 4 0 (6) a group of formula: ** Formula ** in which It is already a group selected from the following (i) to (iii) : (i) C1-6 alkylene, (ii) -C (>; = O) - or (iii) -C (>; = O) -O-, Ring T is: (i) C6-10 aryl, (ii ) C3-10 cycloalkyl or (iii) saturated monoheterocyclyl wherein the saturated monoheterocyclyl comprises 1 to 4 heteroatoms selected from a nitrogen atom, an oxygen atom or a sulfur atom, as well as carbon atoms and the number of constituent atoms in the ring it is 3 to 7, Rc5 is the same or different and each one is: (i) cyano or (ii) nitro, p is an integer selected from 0 to 4, Group A is the group consisting of: (a) hydroxy, (b) C1-6 alkoxy, (c) cyano, (d) C1-6 alkoxycarbonylo, (e) C1-6 alkylcarbonyloxy and (f) C2-6 alkenyloxy or a pharmaceutically acceptable salt thereof or a Solvate of it.Un compuesto de la siguiente fórmula general [I]: **Fórmula** en la que Ra es igual o diferente y cada uno es: (1) alquilo C1-6 o (2) un átomo de h
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