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Interleukin-2/Interleukin-2 Receptor alpha fusion proteins and methods of use
专利权人:
University of Miami
发明人:
Malek, Thomas
申请号:
AU2015301071
公开号:
AU2015301071A1
申请日:
2015.08.05
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2Rα ) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2Rα fusion protein disclosed herein.
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