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Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system
专利权人:
PIRAMAL IMAGING SA
发明人:
THIELE ANDREA,KETTSCHAU GEORG,HEINRICH TOBIAS,LEHMANN LUTZ,HALLDIN CHRISTER,NAG SANGRAM,VARRONE ANDREA,GULYAS BALAZS
申请号:
NZ61073611
公开号:
NZ610736A
申请日:
2011.10.17
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
The disclosure relates to compounds of the general formula I, wherein D is deuterium, R1 is selected from methyl, ethyl, n-propyl, n-butyl, iso-butyl; R2 is fluorine, [18F]fluorine or a leaving group, wherein leaving groups are selected from halogen, C1-C6-alkylsulfonyloxy, which is optionally substituted by fluorine, and arylsulfonyloxy, which is optionally substituted by hydrogen, methyl, halo and nitro; n and m are selected from 0 and 1 with the proviso that if n = 0, m must be 1, and if n = 1, m must be 0, and if R2 is fluorine, n must be 1 and m must be 0. The disclosure also relates to the [18F] labelled compounds and compositions comprising these compounds for use in PET imaging of CNS diseases, including Alzheimer’s disease. The disclosure also relates to a method to synthesise these compounds and kits containing them.
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