ANTI INTEGRIN ANTIBODIES LINKED TO NANOPARTICLES LOADED WITH CHEMOTHERAPEUTIC AGENTS

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专利权人:

发明人:

LANGER KLAUS,ANHORN MARION,KREUTER JOERG,ROTHWEILER FLORIAN,VON BRIESEN HAGEN,WAGNER SYLVIA,MICHAELIS MARTIN,CINATL JINDRICH

申请号：

IN1419/KOLNP/2012

公开号：

IN2012KN01419A

申请日:

2012.06.11

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The invention relates to anti-integrin antibodies which are covalently linked to nanoparticles, wherein these nanoparticles were prior loaded with chemotherapeutic / cytotoxic agents. The antibody-chemotherapeutic agent- nanoparticle conjugates according to the invention, especially wherein the antibody is MAb DI17E6 and the cytotoxic agent is doxorubicin show a significant increase of tumor cell toxicity.

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中国工程科技知识中心

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http://www.ckcest.cn/home/