以CCR6或CXCR2之拮抗劑治療廣泛性膿疱型乾癬之方法农业专利-农业专业知识服务系统

发明人:: CAMPBELL, JAMES J.,坎贝尔　詹姆士　Ｊ,坎貝爾　詹姆士　Ｊ,EBSWORTH, KAREN,埃布斯沃思　凯伦,埃布斯沃思　凱倫,KRASINSKI, ANTONI,克瑞辛斯基　安东尼,克瑞辛斯基　安東尼,MALI, VENKAT REDDY,马利　帆克　罗迪,馬利　帆克　羅迪,MCMAHON, JEFFREY,马克马宏　杰夫瑞,馬克馬宏　傑夫瑞,SINGH, RAJINDER,斯

摘要：: The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula:.本發明尤其提供一種藉由投與有效量之趨化介素受體6 (CCR6)拮抗劑及/或C-X-C基元趨化介素受體2 (CXCR2)拮抗劑來治療廣泛性膿疱型乾癬(GPP)之方法。本發明亦提供一種調節有需要個體中失調IL-36信號傳導之方法，及減少有需要個體中嗜中性球、發炎性樹突狀細胞(iDC)及/或CD4 T細胞積聚之方法，該等方法包括投與有效量之趨化介素受體6 (CCR6)拮抗劑及/或C-X-C基元趨化介素受體2 (CXCR2)拮抗劑。在一些實施例中，CCR6及/或CXCR2拮抗劑具有下式：。