Cancer markers and therapeutic targets

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专利权人:

キャンサー・リサーチ・テクノロジー・リミテッド

发明人:

フランシス バルクウィル,ヴァイオレット スレテナー,ジュリア ウィルソン,ヤオヘ ワング,ティジアナ シチオッパ

申请号：

JP2010525420

公开号：

JP5774309B2

申请日:

2008.09.18

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

Chemokine receptor CCR4 and its ligands CCL17 and CCL22 are used as markers for the identification and/or staging of cancer. The level of CCR4, CCL17 and CCL22 are found to increase during malignant tumour progression. CCR4, CCL17 and CCL22 are used as markers for the stratification of cancer patients according to their suitability for treatment with anti-cancer agents. Information of diagnostic character is provided by measuring the level of one or more of CCR4, CCL17 and CCL22 present in a patient sample. Methods of treatment of cancer patients which agents that modulate the activity of CCR4, CCL17 and CCL22. Methods of screening for agents which modulate the biological activities of CCR4, CCL17 and CCL22 provide anti-cancer agents.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/