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PROMOTERS FOR SPECIFIC LIVER LEVEL DELIVERY AND BETTER TOLERANCE
专利权人:
LILIANE THERESE JACQUOT;JACQUES PAUL DJIAN
发明人:
LILIANE THERESE JACQUOT,JACQUES PAUL DJIAN
申请号:
FR1100060
公开号:
FR2970178B1
申请日:
2011.01.07
申请国别(地区):
FR
年份:
2014
代理人:
摘要:
The invention relates to a prodrug intended to be specifically dispensed to the liver. The invention relates to a prodrug with the general formula (I) X-R, wherein X is a therapeutic agent, the site of action of which is the liver and R is a saturated or unsaturated, straight or branched fatty acid, including 3 to 12 carbon atoms, optionally substituted with one or more hydroxyl groupings, halogen atom and cyclic hydrocarbon including 3 to 6 carbon atoms, or a pharmaceutically acceptable salt or stereoisomer thereof. The invention also relates to a pharmaceutical composition containing at least one prodrug according to the invention associated with a suitable carrier, specifically for oral delivery. The invention further relates to the use of a prodrug according to the invention or of a pharmaceutical composition in the preparation of a drug for treating or preventing various diseases.
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中国工程科技知识中心
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