A method for operating in a system for repetitive local puncturing of skin is provided. The system having a handheld applicator device provided with a puncturing device configured to repetitively puncture skin and a control device connected to the handheld applicator device and configured to control operation of the applicator device. The method comprising: receiving a user selection for a body skin part to which repetitive local puncturing is to be applied in the control device, responsively providing a set of operation parameters in the control device, the set of operation parameters defining a mode of operation of the applicator device for repetitive local puncturing, and operating the applicator device according to the mode of operation defined by the set of operation parameters with the operating of the applicator device being controlled by the control device. Also, a system for repetitive local puncturing a skin is provided.
