A biopsy device includes a disposable unit including a needle carrier and a biopsy needle. The biopsy needle has a distal portion including a sample chamber and a hub portion located proximal to the sample chamber. The needle carrier has a holding portion. The holding portion and the hub portion are collectively configured to form a detent mechanism configured to permit the biopsy needle to rotate within needle carrier to rotationally position the sample chamber while restraining rotation of the biopsy needle at a series of rotational detent positions.
