Xiaofang Wen,Yiliang Wu,Yefei Wang,Zhiyu Yang,Min Fan,Yujiao Wang,Xiaochun Fang,You Lu
申请号：
US13575752
公开号：
US08785597B2
申请日:
2010.06.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.
