Gregor MEYERS,Andreas EGE,Christiane MEYER,Martina von FREYBURG
申请号：
US13655278
公开号：
US20130039946A1
申请日:
2012.10.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Ems and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Ems in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
