ENZYMATIC MODIFICATION OF ANTI-AQP4 AUTOANTIBODY FOR MODULATING NEUROMYELITIS OPTICA

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专利权人:

The Regents of the University of California

发明人:

Alan S. Verkman,Lukmanee Tradtrantip

申请号：

US14402579

公开号：

US20150139981A1

申请日:

2013.05.21

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Provided herein is a method of treating neuromyelitis optica (NMO) in an animal or human subject comprising administering to the subject a composition comprising a therapeutically effective amount of an Fc region modified anli-AQP4 antibody, thereby treating the NMO in the subject, in some embodiments, the Fc region modified anti-AQP4 antibody is an anti-AQP4 antibody deglycosylated at the amino acid position Asn297. In other embodiments, the Fc region modified anti-AQP4 antibody is an anii-AQP4 antibody F(ab′)2 fragment.

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