To produce a nest spleen equivalent to a nest made by a honey bee in a natural environment by injection molding of a thermoplastic resin.SOLUTION: The honeycomb structure has a base portion 2 formed in a hexagonal prism shape, a core portion 4 formed in a hexagonal prism shape which is radially inwardly diametric than the base portion 2 at the upper end of the base portion 2, A step surface 6 in which a boundary portion between the core portion 2 and the core portion 4 is formed in a stepped shape and a belt-like concave portion 8 formed on the side surface of the base portion 2 from the step surface to the lower end surface of the base portion 2 A method of manufacturing an artificial nest spleen having a mold clamping step in which a movable side mold formed by arranging metal molds consisting of metal foils is arranged in butt against a fixed side mold to form a cavity and the cavity and the band-.(FIG.【課題】蜜蜂が自然環境下で作った巣と同等の巣脾を熱可塑性樹脂の射出成形で製造する。【解決手段】六角柱状に形成されてなる基礎部2と、基礎部2の上端に基礎部2よりも径方向内方に縮径された六角柱状に形成されてなるコア部4と、基礎部2とコア部4との境界部分が段差状に形成されてなるステップ面6と、基礎部2の側面に、ステップ面から基礎部2の下端面にかけて形成されてなる帯状凹部8とを有してなる金型が配列されてなる可動側金型を、固定側金型に突き合わせてキャビティを形成すると共に、前記キャビティと帯状凹部8とが連通される型締め工程を有する人工巣脾の製造方法。【選択図】図3