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MUTATIONS DE BRAF CONFERANT UNE RESISTANCE AUX INHIBITEURS DE BRAF
专利权人:
INC.;DANA-FARBER CANCER INSTITUTE
发明人:
GARRAWAY, LEVI,EMERY, CAROLINE
申请号:
CA2789696
公开号:
CA2789696C
申请日:
2011.02.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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