MUTATIONS DE BRAF CONFERANT UNE RESISTANCE AUX INHIBITEURS DE BRAF

• 收藏
• 分享

专利权人:

INC.;DANA-FARBER CANCER INSTITUTE

发明人:

GARRAWAY, LEVI,EMERY, CAROLINE

申请号：

CA2789696

公开号：

CA2789696C

申请日:

2011.02.22

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/