Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function

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专利权人:

Che-Kun James Shen

发明人:

Che-Kun James Shen,Lien-Szu Wu

申请号：

US13166147

公开号：

US08476485B2

申请日:

2011.06.22

申请国别(地区):

US

年份:

2013

代理人:

摘要：

A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The animal model comprises a rodent whose spinal cord motor neurons have a loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. A method for identifying a candidate agent for treating, preventing and/or inhibiting ALS associated with a loss-of-function of TDP-43 is also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/