A method of using a transfer factor formulation to improve the success rate of a human COS or COS/IUI procedure. The transfer factor formulation consists of at least transfer factor, and may also include lactic acid generating bacteria, and/or glucans. The transfer factor formulation, administered correctly, improves the probability of achieving conception via COS/IUI. Both men and women can receive transfer factor formulation. Dosage amounts are adjusted for body weight. Consumption frequency may be adjusted in response to hormonal measurements. Typically, consumption of the formulation begins three to 100 days before a planned COS/IUI procedure.