KONDRU, RAMA K.,LOU, YAN,SJOGREN, ERIC BRIAN,SOTH, MICHAEL
申请号：
CA2725512
公开号：
CA2725512C
申请日:
2009.07.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
6-Phenyl-imidazo[1,2-a]pyrazine derivatives according to generic Formulae I-V:wherein variables Q, R, Y1, Y2,Y3, Y4, n, and m are defined as described herein, which inhibit Btk. Thecompounds disclosed herein are useful to modulate theactivity of Btk and treat diseases associated with excessive Btk activity. Thecompounds are further useful to treat inflammatoryand auto immune diseases associated with aberrant B-cell proliferation such asrheumatoid arthritis. Also disclosed are compositionscomprising compounds of Formulae I-V and at least one carrier, diluent orexcipient.
